Multiple locations in Iran have been targeted by joint US-Israel strikes, and Tehran has launched retaliatory missiles across the region.
The Iranian cities hit on Saturday include Tehran, Isfahan, Tabriz, Kermanshah, and Qom, according to Telegram posts from the country's Revolutionary Guard Corps.
Also targeted was the residence of Supreme Leader Ayatollah Ali Khamenei, as well as the nation's intelligence ministry, its defence ministry, and its Atomic Energy Organization, Sky News understands.
In a social media post on Saturday, US President Donald Trump pronounced the ayatollah dead, a fact eventually confirmed by Iranian state media.
Initially officials had said Khamenei was not there at the time and remained in charge.
Satellite imagery of the leader's compound on Saturday showed black smoke and extensive damage, with at least four buildings struck.
A fresh wave of strikes began on Sunday, and Iran hit back once again, with bangs heard over Dubai on Sunday.
In the ongoing war of words alongside the military conflict, Iran's Revolutionary Guard on Sunday vowed "severe, decisive and regret-inducing punishment".
A few hours later President Donald Trump said they had "better not do that" because otherwise the US would "hit them with a force that has never been seen before".
The conflict is the culmination of weeks of threats and broke out on Saturday morning despite apparent progress during talks in Geneva this week.
The Iranian Red Crescent said more than 200 people have been killed since yesterday morning.
According to the Iranian Health Ministry, more than 60 students were killed and 80 more injured in a strike at a girls' school in Minab, a city in Hormozgan province.
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Iran soon hit back on Saturday, simultaneously striking four US bases across the Middle East.
These were Al Udeid Air Base in Qatar, Al Salem base in Kuwait, Al Dhafra Air Base in the United Arab Emirates, and the US Fifth Fleet base in Bahrain.
The attack on the US Navy's Fifth Fleet centre was also reported by Bahraini state news agency BNA.
At least three large bangs were heard in Dubai on Saturday, with video later emerging showing damage to the airport.
More video from social media showed a fire near the entrance of Dubai's Fairmont The Palm hotel, reportedly after debris fell from the sky during an Iranian missile attack.
At least one person has been killed in the UAE. Another four were killed in Syria, when a missile struck a building in the south of the country, the state-owned SANA news agency reported.
While in Kuwait, several employees at the nation's only commercial airport were injured by a drone, which also damaged Terminal 1, according to the country's Directorate General of Civil Aviation.
There have been no reported American casualties, two officials told our US partner NBC News.
The Revolutionary Guard said it considers "all US bases, resources, and interests in the region to be legitimate targets" for retaliation.
(c) Sky News 2026: Where has been hit? Iran retaliates across Middle East after US-Israel strikes
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